Profile of Sabeeha Merchant.
نویسنده
چکیده
Organic molecules dominate the biological world, yet many of life’s critical molecular reactions depend on metals for catalysis. Sabeeha Merchant, a professor of biochemistry at the University of California, Los Angeles (UCLA), studies how cells keep track of crucial trace nutrients like iron and copper. Her early work on Chlamydomonas reinhardtii, a single-celled alga that, like all plants, primarily uses a copper-based electron transporter during photosynthesis, revealed that the organism engages an alternate, iron-dependent molecule when copper availability is low (1). Merchant, elected to the National Academy of Sciences in 2012, says, “I always get asked, ‘Why have two pathways?’” In her Inaugural Article, Merchant provides experimental support for plastocyanin as a de facto copper storage molecule. The protein is active during times of copper sufficiency but gets degraded to liberate its copper stores for other essential needs when the backup pathway is initiated in copper-deficient environments (2).
منابع مشابه
Trace Metal Utilization in Chloroplasts
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متن کاملMetabolism in Chlamydomonas Grossman et al. Novel metabolism in Chlamydomonas through the lens of genomics
Novel metabolism in Chlamydomonas through the lens of genomics Arthur R Grossman, Martin Croft, Vadim N Gladyshev, Sabeeha S Merchant, Matthew C Posewitz, Simon Prochnik and Martin H Spalding Chlamydomonas has traditionally been exploited as an organism that is associated with sophisticated physiological, genetic and molecular analyses, all of which have been used to elucidate several biologica...
متن کاملThe g-Carbonic Anhydrase Subcomplex of Mitochondrial Complex I Is Essential for Development and Important for Photomorphogenesis of Arabidopsis1[C][W][OA]
College of Biological Sciences, Hunan University, Changsha 410082, China (Q.W.); Department of Chemistry and Biochemistry (R.F., S.S.M.) and Department of Molecular, Cell, and Developmental Biology (Q.W., X.Y., Z.C., H.L., Y.L., C.L.), University of California, Los Angeles, California 90095; and State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University...
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ورودعنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 112 9 شماره
صفحات -
تاریخ انتشار 2015